Many physiologic effects of l-glutamate, the major excitatory neurotransmitter in the
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …

GluN3-containing NMDA receptors (GluN3-NMDARs) are rarer than the'classical'NMDARs,
which are composed solely of GluN1 and GluN2 subunits, and have non-conventional …

Ketamine is widely used as a pediatric anesthetic. Studies in developing rodents have
indicated that ketamine-induced anesthesia results in brain cell death. Additional studies are …

During development there is an activity-dependent switch in synaptic N-Methyl-D-aspartate
(NMDA) receptor subunit composition from predominantly GluN2B to GluN2A, though the …

NMDA-type glutamate receptors are ligand-gated ion channels that mediate a major
component of excitatory neurotransmission in the central nervous system (CNS). They are …

Among diverse factors regulating excitatory synaptic transmission, the abundance of
postsynaptic glutamate receptors figures prominently in molecular memory and learning …

Switching of the NMDA receptor 2A (NR2A) and NR2B subunits at NMDA receptors is
thought to underlie the functional changes that occur in NMDA receptor properties during the …

Neuropathic pain remains a major clinical problem and a therapeutic challenge because
existing analgesics are often ineffective and can cause serious side effects. Increased N …

In childhood, the risk for seizures is greatest in the neonatal period. Currently used therapies
have limited efficacy. Although the treatment of neonatal seizures has not significantly …

There is a growing body of evidence linking maternal overnutrition to obesity and
psychopathology that can be conserved across multiple generations. Recently, we …