Integrin receptors are the main molecular link between cells and the extracellular matrix
(ECM) as well as mediating cell–cell interactions. Integrin–ECM binding triggers the …

Endocytosis allows cells to transport particles and molecules across the plasma membrane.
In addition, it is involved in the termination of signalling through receptor downmodulation …

Cell polarity, which consists of the morphological, structural, and functional organization of
cells along a defined axis, is a feature of healthy cells and tissues. In contrast, abnormal …

Epithelial-mesenchymal transition (EMT) refers to a process in which epithelial cells lose
apical-basal polarity and loosen cell–cell junctions to take on mesenchymal cell …

CD47 is overexpressed in many human cancers, its level positively correlates with tumor
invasion and metastasis. However, it is largely unknown whether CD47 overexpression …

There is strong evidence supporting the role of the plasminogen activator system in head
and neck squamous cell carcinoma (HNSCC), particularly of its uPA (urokinase …

B7-H3 is a tumor-promoting glycoprotein that is expressed at low levels in most normal
tissues, but is overexpressed in various human cancers which is associated with disease …

The goal of this study was to understand if exosomes derived from high-metastatic cells may
influence the behavior of less aggressive cancer cells and the properties of the endothelium …

The Hippo signal transduction pathway is an important regulator of organ growth and cell
differentiation, and its deregulation contributes to the development of cancer. The activity of …

The distribution of biomolecules within cells changes upon aging and diseases. To
quantitatively determine the spatial distribution of components inside cells, we built the user …