Efficacy of peroxisome proliferator-activated receptor agonists, glucagon-like peptide-1 receptor agonists, or sodium-glucose cotransporter-2 inhibitors for treatment of …

A Mantovani, CD Byrne, G Targher - The lancet Gastroenterology & …, 2022 - thelancet.com
There are no licensed treatments for non-alcoholic fatty liver disease (NAFLD), but three
different classes of antihyperglycaemic drugs—peroxisome proliferator-activated receptor …

Integrins as a drug target in liver fibrosis

SR Rahman, JA Roper, JI Grove, GP Aithal… - Liver …, 2022 - Wiley Online Library
As the worldwide prevalence of chronic liver diseases is high and continuing to increase,
there is an urgent need for treatment to prevent cirrhosis‐related morbidity and mortality …

Hepatocytes demarcated by EphB2 contribute to the progression of nonalcoholic steatohepatitis

Y Xiao, K Batmanov, W Hu, K Zhu, AY Tom… - Science translational …, 2023 - science.org
Current therapeutic strategies for treating nonalcoholic steatohepatitis (NASH) have failed to
alleviate liver fibrosis, which is a devastating feature leading to hepatic dysfunction. Here …

Global trends and hotspots of treatment for nonalcoholic fatty liver disease: A bibliometric and visualization analysis (2010-2023)

JJ Dai, YF Zhang, ZH Zhang - World Journal of …, 2023 - pmc.ncbi.nlm.nih.gov
BACKGROUND Nonalcoholic fatty liver disease (NAFLD) is chronic, with its progression
leading to liver fibrosis and end-stage cirrhosis. Although NAFLD is increasingly common …

Lipotoxicity as the leading cause of non-alcoholic steatohepatitis

M Branković, I Jovanović, M Dukić, T Radonjić… - International Journal of …, 2022 - mdpi.com
The emerging issues nowadays are non-alcoholic fatty liver disease (NAFLD) and its
advanced stage non-alcoholic steatohepatitis (NASH), which further can be a predisposing …

Hepatoprotective effects of semaglutide, lanifibranor and dietary intervention in the GAN diet‐induced obese and biopsy‐confirmed mouse model of NASH

MB Møllerhøj, SS Veidal, KT Thrane… - Clinical and …, 2022 - Wiley Online Library
Non‐alcoholic steatohepatitis (NASH) has emerged as a major challenge for public health
because of high global prevalence and lack of evidence‐based therapies. Most animal …

The role of protein kinases as key drivers of metabolic dysfunction-associated fatty liver disease progression: New insights and future directions

S Alshehade, MA Alshawsh, V Murugaiyah, M Asif… - Life sciences, 2022 - Elsevier
Metabolic dysfunction-associated fatty liver disease (MAFLD), proposed in 2020 is a novel
term for non-alcoholic fatty liver disease (NAFLD) which was coined for the first time in 1980 …

[HTML][HTML] Gomisin D alleviates liver fibrosis through targeting PDGFRβ in hepatic stellate cells

R Wang, F Liu, P Chen, S Li, Y Gu, L Wang… - International Journal of …, 2023 - Elsevier
Platelet-derived growth factor receptor β (PDGFRβ) plays an important role in hepatic
fibrosis and is closely associated with hepatic stellate cells (HSCs) activation. Previously, by …

Targeting chronic liver diseases: Molecular markers, drug delivery strategies and future perspectives

J Unagolla, S Das, R Flanagan, M Oehler… - International Journal of …, 2024 - Elsevier
Chronic liver inflammation, a pervasive global health issue, results in millions of annual
deaths due to its progression from fibrosis to the more severe forms of cirrhosis and …

Understanding the burden of nonalcoholic fatty liver disease: time for action

ZM Younossi, L Henry - Diabetes Spectrum, 2024 - Am Diabetes Assoc
The prevalence of nonalcoholic fatty liver disease (NAFLD) in the United States is 38%,
having increased by 50% within the past 3 decades. The estimated NAFLD prevalence …