Humans have, throughout history, faced periods of starvation necessitating increased
physical effort to gather food. To explore adaptations in muscle function, 13 participants (7 …

Generally, fasting and refeeding confer anti-and proinflammatory effects, respectively. In
humans, these caloric-load interventions function, in part, via regulation of CD4+ T cell …

Metabolic reprogramming of CD4 T cells has become an opportunity for adjunctive
therapies. Here, Han et al. show that boosting NAD+ blunts systemic Th17 responses and …

Alzheimer's disease (AD) is distinguished by cognitive dysfunction and neuroinflammation in
the brain. 2′-Fucosyllactose (2′-FL) is a major human milk oligosaccharide (HMO) that is …

Lipid-derived acetyl-CoA is shown to be the major carbon source for histone acetylation.
However, there is no direct evidence demonstrating lipid metabolic pathway contribututions …