Upon massive DNA damage cells fail to undergo productive DNA repair and trigger the cell
death response. Resistance to cell death is linked to cellular transformation and …

Members of the tripartite motif (TRIM) protein family are involved in various cellular
processes, including cell proliferation, differentiation, development, oncogenesis and …

Cellular bodies such as P bodies and PML nuclear bodies (PML NBs) appear to be phase-
separated liquids organized by multivalent interactions among proteins and RNA molecules …

PML nuclear bodies (NBs) are nuclear structures that have been implicated in processes
such as transcriptional regulation, genome stability, response to viral infection, apoptosis …

An estimated eight million people are infected each year with the pathogen Mycobacterium
tuberculosis, and more than two million die annually. Yet only about 10% of those infected …

Epidemiologic studies have found an inverse association between consumption of tomato
products and the risk of certain types of cancers. However, the mechanisms underlying this …

The mechanistic interconnectivity between circadian regulation and the genotoxic stress
response remains poorly understood. Here we show that the expression of Period 2 (Per2) …

The tumour suppressor HIPK2 is an important regulator of cell death induced by DNA
damage, but how its activity is regulated remains largely unclear. Here we demonstrate that …

The promyelocytic leukemia protein (PML) is a tumor suppressor identified in acute PML and
implicated in the pathogenesis of a variety of tumors. PML is essential for the proper …

Adenovirus replication is controlled by the relocalization or modification of nuclear protein
complexes, including promyelocytic leukemia protein (PML) nuclear domains and the Mre11 …