Bacteria live in environments that are subject to rapid changes in the availability of the
nutrients that are necessary to provide energy and biosynthetic intermediates for the …

The uptake of nutrients, including metals, amino acids and peptides are required for many
biological processes. Pathogenic bacteria scavenge these essential nutrients from …

A precise understanding of the genomic organization into transcriptional units and their
regulation is essential for our comprehension of opportunistic human pathogens and how …

Streptococcus pneumoniae is a leading cause of community-acquired pneumonia and
bacteraemia and is capable of remarkable phenotypic plasticity, responding rapidly to …

How bacteria sense and respond to nitrogen levels are central questions in microbial
physiology. In Gram-positive bacteria, nitrogen homeostasis is controlled by an operon …

Background Pneumonia remains the leading cause of death in young children globally and
improved diagnostics are needed to better identify cases and reduce case fatality …

Gram-positive bacteria have developed elaborate mechanisms to control ammonium
assimilation, at the levels of both transcription and enzyme activity. In this review, the …

The metabolism of Streptococcus pneumoniae was studied by isotopologue profiling after
bacterial cultivation in chemically defined medium supplemented with [U-13 C 6]-or [1, 2-13 …

Background Streptococcus pneumoniae is a common colonizer of the human nasopharynx
and one of the major pathogens causing invasive disease worldwide. Dissection of the …

The high environmental adaptability of bacteria is contingent upon their ability to sense
changes in their surroundings. Bacterial pathogen entry into host poses an abrupt and …