Comparative metagenomic analysis of biosynthetic diversity across sponge microbiomes highlights metabolic novelty, conservation, and diversification
C Loureiro, A Galani, A Gavriilidou… - …, 2022 - Am Soc Microbiol
Marine sponges and their microbial symbiotic communities are rich sources of diverse
natural products (NPs) that often display biological activity, yet little is known about the …
natural products (NPs) that often display biological activity, yet little is known about the …
Metagenomic Exploration of the Marine Sponge Mycale hentscheli Uncovers Multiple Polyketide-Producing Bacterial Symbionts
MA Storey, SK Andreassend, J Bracegirdle, A Brown… - MBio, 2020 - Am Soc Microbiol
Marine sponges have been a prolific source of unique bioactive compounds that are
presumed to act as a deterrent to predation. Many of these compounds have potential …
presumed to act as a deterrent to predation. Many of these compounds have potential …
Horizontal gene transfer to a defensive symbiont with a reduced genome in a multipartite beetle microbiome
Symbiotic mutualisms of bacteria and animals are ubiquitous in nature, running a continuum
from facultative to obligate from the perspectives of both partners. The loss of functions …
from facultative to obligate from the perspectives of both partners. The loss of functions …
Uncovering Lasonolide A biosynthesis using genome-resolved metagenomics
Invertebrates, particularly sponges, have been a dominant source of new marine natural
products. For example, lasonolide A (LSA) is a potential anticancer molecule isolated from …
products. For example, lasonolide A (LSA) is a potential anticancer molecule isolated from …
Discovery of an Antarctic Ascidian-Associated Uncultivated Verrucomicrobia with Antimelanoma Palmerolide Biosynthetic Potential
The Antarctic marine ecosystem harbors a wealth of biological and chemical innovation that
has risen in concert over millennia since the isolation of the continent and formation of the …
has risen in concert over millennia since the isolation of the continent and formation of the …
The who, why, and how of small-molecule production in invertebrate microbiomes: basic insights fueling drug discovery
JC Kwan - Msystems, 2018 - Am Soc Microbiol
Bacteria have supplied us with many bioactive molecules for use in medicine and
agriculture. However, rates of discovery have decreased as the biosynthetic capacity of the …
agriculture. However, rates of discovery have decreased as the biosynthetic capacity of the …