[HTML][HTML] Network-based approaches for modeling disease regulation and progression

G Galindez, S Sadegh, J Baumbach… - Computational and …, 2023 - Elsevier
Molecular interaction networks lay the foundation for studying how biological functions are
controlled by the complex interplay of genes and proteins. Investigating perturbed processes …

Roles of peripheral clocks: lessons from the fly

E Yildirim, R Curtis, DS Hwangbo - FEBS letters, 2022 - Wiley Online Library
To adapt to and anticipate rhythmic changes in the environment such as daily light–dark and
temperature cycles, internal timekeeping mechanisms called biological clocks evolved in a …

Time series transcriptome analysis implicates the circadian clock in the Drosophila melanogaster female's response to sex peptide

SYN Delbare, S Venkatraman… - Proceedings of the …, 2023 - National Acad Sciences
Sex peptide (SP), a seminal fluid protein of Drosophila melanogaster males, has been
described as driving a virgin-to-mated switch in females, through eliciting an array of …

On a method for detecting periods and repeating patterns in time series data with autocorrelation and function approximation

T Breitenbach, B Wilkusz, L Rasbach, P Jahnke - Pattern Recognition, 2023 - Elsevier
Detecting recurrent patterns in time series data is an important capability. The reason is that
repeating patterns on the one hand indicate well defined processes that can be further …

Viruses in Laboratory Drosophila and Their Impact on Host Gene Expression

O Kuyateh, DJ Obbard - Viruses, 2023 - mdpi.com
Drosophila melanogaster has one of the best characterized antiviral immune responses
among invertebrates. However, relatively few easily transmitted natural virus isolates are …

Central and peripheral clock control of circadian feeding rhythms

CV Fulgham, AP Dreyer, A Nasseri… - Journal of biological …, 2021 - journals.sagepub.com
Many behaviors exhibit~ 24-h oscillations under control of an endogenous circadian timing
system that tracks time of day via a molecular circadian clock. In the fruit fly, Drosophila …

Clockwork orange promotes CLOCK-CYCLE activation via the putative Drosophila ortholog of clock interacting protein circadian

GBS Rivas, J Zhou, C Merlin, PE Hardin - Current Biology, 2021 - cell.com
The Drosophila circadian clock is driven by a transcriptional feedback loop in which CLOCK-
CYCLE (CLK-CYC) binds E-boxes to transcribe genes encoding the PERIOD-TIMELESS …

Circadian‐mediated regulation of cardiometabolic disorders and aging with time‐restricted feeding

JR Roth, S Varshney, RCM de Moraes, GC Melkani - Obesity, 2023 - Wiley Online Library
Circadian rhythms are present throughout biology, from the molecular level to complex
behaviors such as eating and sleeping. They are driven by molecular clocks within cells …

Regulation of feeding and energy homeostasis by clock-mediated Gart in Drosophila

L He, B Wu, J Shi, J Du, Z Zhao - Cell Reports, 2023 - cell.com
Feeding behavior is essential for growth and survival of animals; however, relatively little is
known about its intrinsic mechanisms. Here, we demonstrate that Gart is expressed in the …

Keeping time in the dark: Potato diel and circadian rhythmic gene expression reveals tissue‐specific circadian clocks

GM Hoopes, D Zarka, A Feke, K Acheson… - Plant …, 2022 - Wiley Online Library
The circadian clock is an internal molecular oscillator and coordinates numerous
physiological processes through regulation of molecular pathways. Tissue‐specific clocks …