Fine-mapping causal tissues and genes at disease-associated loci
Complex diseases often have distinct mechanisms spanning multiple tissues. We propose
tissue–gene fine-mapping (TGFM), which infers the posterior inclusion probability (PIP) for …
tissue–gene fine-mapping (TGFM), which infers the posterior inclusion probability (PIP) for …
Integrative analysis of the genome, transcriptome, and proteome identifies causal mechanisms of complex traits
We present multi-integration of transcriptome-wide association studies and colocalization
(Multi-INTACT), an algorithm that models multiple gene products (eg encoded RNA …
(Multi-INTACT), an algorithm that models multiple gene products (eg encoded RNA …
Fine-mapping variants and genes that contribute to celiac disease
R Broekema - 2023 - research.rug.nl
Complex diseases like type-1 diabetes, multiple sclerosis, and celiac disease (CeD) are
difficult to unravel from a genetic perspective because they are caused by many mutations …
difficult to unravel from a genetic perspective because they are caused by many mutations …
Statistical Methods for Causal Gene Implication in Integrative Genetic Association Analyses
J Okamoto - 2024 - deepblue.lib.umich.edu
Improvements in sequencing technologies over the past several years have led to numerous
successful genome-wide association studies (GWAS) that reveal variant-level genetic …
successful genome-wide association studies (GWAS) that reveal variant-level genetic …