G Gagliardi, KB M'Barek, O Goureau - Progress in retinal and eye research, 2019 - Elsevier
The human retina fails to regenerate and cell-based therapies offer options for treatment of blinding retinal diseases, such as macular degeneration and retinitis pigmentosa. The last …
To study the development of the human retina, we use single-cell RNA sequencing (RNA- seq) at key fetal stages and follow the development of the major cell types as well as …
The development of single-cell RNA sequencing (scRNA-seq) has allowed high-resolution analysis of cell-type diversity and transcriptional networks controlling cell-fate specification …
H Liu, Y Zhang, YY Zhang, YP Li… - Proceedings of the …, 2020 - National Acad Sciences
Retinoblastoma (Rb) is the most prevalent intraocular malignancy in children, with a worldwide survival rate< 30%. We have developed a cancerous model of Rb in retinal …
K Shekhar, JR Sanes - Annual Review of Vision Science, 2021 - annualreviews.org
It has been known for over a century that the basic organization of the retina is conserved across vertebrates. It has been equally clear that retinal cells can be classified into …
B Dorgau, J Collin, A Rozanska, D Zerti… - Nature …, 2024 - nature.com
The emergence of retinal progenitor cells and differentiation to various retinal cell types represent fundamental processes during retinal development. Herein, we provide a …
Snakes are a remarkable squamate lineage with unique morphological adaptations, especially those related to the evolution of vertebrate skeletons, organs, and sensory …
CM Bell, DJ Zack, CA Berlinicke - Annual review of vision …, 2020 - annualreviews.org
Recent advances in stem cell engineering have led to an explosion in the use of organoids as model systems for studies in multiple biological disciplines. Together with breakthroughs …
A major goal in the stem cell field is to generate tissues that can be utilized as a universal tool for in vitro models of development and disease, drug development, or as a resource for …