The p63 gene is a member of the p53/p63/p73 family of transcription factors and plays a
critical role in development and homeostasis of squamous epithelium. p63 is transcribed as …

Squamous cell carcinoma (SCC) is an aggressive malignancy that can originate from
various organs. TP63 is a master regulator that plays an essential role in epidermal …

Exceptionally long-lived species, including many bats, rarely show overt signs of aging,
making it difficult to determine why species differ in lifespan. Here, we use DNA methylation …

Variation in lung alveolar development is strongly linked to disease susceptibility. However,
underlying cellular and molecular mechanisms are difficult to study in humans. We have …

Our knowledge of transcriptional heterogeneities in epithelial stem and progenitor cell
compartments is limited. Epidermal basal cells sustain cutaneous tissue maintenance and …

During embryonic development, hierarchical cascades of transcription factors interact with
lineage-specific chromatin structures to control the sequential steps in the differentiation of …

The Hippo TEAD-transcriptional regulators YAP1 and TAZ are central for cell renewal and
cancer growth; however, the specific downstream gene networks involved in their activity are …

Aplasia cutis congenita (ACC) is a congenital epidermal defect of the midline scalp and has
been proposed to be due to a primary keratinocyte abnormality. Why it forms mainly at this …

Stem cells undergo cellular division during their differentiation to produce daughter cells
with a new cellular identity. However, the epigenetic events and molecular mechanisms …

Human limbs emerge during the fourth post-conception week as mesenchymal buds, which
develop into fully formed limbs over the subsequent months. This process is orchestrated by …