The microenvironment encompasses all components of a tumor other than the cancer cells
themselves. It is highly heterogenous, comprising a cellular component that includes …

Connective tissue growth factor, also known as CCN2, is a cysteine-rich matricellular protein
involved in the control of biological processes, such as cell proliferation, differentiation …

Melanomas can have multiple coexisting cell states, including proliferative (PRO) versus
invasive (INV) subpopulations that represent a" go or grow" trade-off; however, how these …

Chronic kidney disease (CKD) is a major health and economic burden with a rising
incidence. During progression of CKD, the sustained release of proinflammatory and …

Background: Recent evidence suggests that cancer and cardiovascular diseases are
associated. Chemotherapy drugs are known to result in cardiotoxicity, and studies have …

CCN family protein 2 (CCN2), also widely known as connective tissue growth factor (CTGF),
is one of the founding members of the CCN family of matricellular proteins. Extensive …

Despite the dramatic advances in cancer research over the decades, effective therapeutic
strategies are still urgently needed. Increasing evidence indicates that connective tissue …

Worldwide deaths from diabetes mellitus (DM) and colorectal cancer increased by 90% and
57%, respectively, over the past 20 years. The risk of colorectal cancer was estimated to be …

Metal and its oxide nanoparticles show ideal pharmacological activity, especially in anti-
tumor therapy. Our previous study demonstrated that cuprous oxide nanoparticles (CONPs) …

Connective tissue growth factor (CTGF), a multifunctional protein of the CCN family,
regulates cell proliferation, differentiation, adhesion, and a variety of other biological …