Eculizumab in atypical hemolytic uremic syndrome: strategies toward restrictive use

KL Wijnsma, C Duineveld, JFM Wetzels… - Pediatric …, 2019 - Springer
With the introduction of the complement C5-inhibitor eculizumab, a new era was entered for
patients with atypical hemolytic uremic syndrome (aHUS). Eculizumab therapy very …

Thrombotic microangiopathy after kidney transplantation: an underdiagnosed and potentially reversible entity

A Ávila, E Gavela, A Sancho - Frontiers in Medicine, 2021 - frontiersin.org
Thrombotic microangiopathy is a rare but serious complication that affects kidney transplant
recipients. It appears in 0.8–14% of transplanted patients and negatively affects graft and …

A British Society for Haematology Guideline: diagnosis and management of thrombotic thrombocytopenic purpura and thrombotic microangiopathies

M Scully, R Rayment, A Clark… - British journal of …, 2023 - Wiley Online Library
The objective of this guideline is to provide healthcare professionals with clear, up‐to‐date
and practical guidance on the management of thrombotic thrombocytopenic purpura (TTP) …

Complement activation and thrombotic microangiopathies

M Palomo, M Blasco, P Molina, M Lozano… - Clinical Journal of the …, 2019 - journals.lww.com
Results Acute phase atypical hemolytic uremic syndrome–activated plasma induced an
increased C5b-9 deposition on endothelial cells. Standard and lower doses of eculizumab …

[HTML][HTML] Consensus regarding diagnosis and management of atypical hemolytic uremic syndrome

H Lee, E Kang, HG Kang, YH Kim, JS Kim… - The Korean Journal …, 2020 - ncbi.nlm.nih.gov
Thrombotic microangiopathy (TMA) is defined by specific clinical characteristics, including
microangiopathic hemolytic anemia, thrombocytopenia, and pathologic evidence of …

[HTML][HTML] Thrombotic microangiopathy after renal transplantation: current insights in de novo and recurrent disease

F Abbas, M El Kossi, JJ Kim, A Sharma… - World journal of …, 2018 - ncbi.nlm.nih.gov
Thrombotic microangiopathy (TMA) is one of the most devastating sequalae of kidney
transplantation. A number of published articles have covered either de novo or recurrent …

[HTML][HTML] “Eculizumab First” in the management of posttransplant thrombotic microangiopathy

F Maritati, V Corradetti, C Bini, M Provenzano… - Kidney International …, 2024 - Elsevier
Introduction Posttransplant thrombotic microangiopathy (PT-TMA) is an uncommon event
that characterizes approximately 3% to 14% of kidney transplants (KTs), and that is …

TMA in kidney transplantation

Z Imanifard, L Liguori, G Remuzzi - Transplantation, 2023 - journals.lww.com
Thrombotic microangiopathy (TMA) is a rare and devastating complication of kidney
transplantation, which often leads to graft failure. Posttransplant TMA (PT-TMA) may occur …

Post-transplant thrombotic microangiopathy due to a pathogenic mutation in complement factor I in a patient with membranous nephropathy: case report and review of …

M Saleem, S Shaikh, Z Hu, N Pozzi, A Java - Frontiers in immunology, 2022 - frontiersin.org
Thrombotic microangiopathy (TMA) is characterized by microangiopathic hemolytic anemia,
thrombocytopenia and organ injury occurring due to endothelial cell damage and …

HUS and TTP: traversing the disease and the age spectrum

R Donadelli, A Sinha, A Bagga, M Noris… - Seminars in …, 2023 - Elsevier
Hemolytic uremic syndrome (HUS) and thrombotic thrombocytopenia purpura (TTP) are rare
diseases sharing a common pathological feature, thrombotic microangiopathy (TMA). TMA is …