Nonsteroidal anti‐inflammatory drugs (NSAIDs) inhibit the enzyme cyclooxygenase (COX),
which forms prostaglandins involved in pain and inflammation. COX inhibitors have …

Chemoprevention is one of the ways to fight colorectal cancer, which is a huge challenge in
oncology. Numerous pieces of evidence indicate that chronic inflammation in the course of …

Vitamins with antioxidant characteristics have been shown as potential chemopreventive
agents because of their roles in quenching free radicals and decreasing oxidative damage …

Background Inheritance patterns show familial clustering of gastrointestinal cancers, and
multiple germline conditions have now been identified that predispose to colorectal, gastric …

Cancer remains a major cause of cancer-related death worldwide. Over 70% of epithelial
malignancies are sporadic and are related to lifestyle. Epidemiological studies suggest an …

Familial adenomatous polyposis (FAP) is a genetic syndrome characterized by the presence
of multiple polyps in the gastrointestinal tract and a wide range of systemic extra-intestinal …

Rapamycin inhibits the mechanistic (formally mammalian) target of rapamycin (mTOR), an
evolutionarily conserved intracellular kinase that influences activation of growth signaling …

Colorectal cancer is a sporadic, hereditary, or familial based disease in its origin, caused
due to diverse set of mutations in large intestinal epithelial cells. Colorectal cancer (CRC) is …

Patients with familial adenomatous polyposis (FAP), an autosomal dominant hereditary
colorectal cancer syndrome, have a lifetime risk of developing cancer of nearly 100 …

Colorectal cancer is a leading cause of cancer-related deaths worldwide. While most cases
are sporadic, a significant proportion of cases are associated with familial and hereditary …