Most solid tumor cells adapt to their heterogeneous microenvironment by depending largely
on aerobic glycolysis for energy production, a phenomenon called the Warburg effect, which …

Cellular metabolism in hematopoietic stem cells (HSCs) is an area of intense research
interest, but the metabolic requirements of HSCs and their adaptations to their niches during …

Bone marrow endothelial cells (BMECs) form a network of blood vessels that regulate both
leukocyte trafficking and haematopoietic stem and progenitor cell (HSPC) maintenance …

Adipose tissue (AT) has previously been identified as an extra-medullary reservoir for
normal hematopoietic stem cells (HSCs) and may promote tumor development. Here, we …

Ever since hematopoietic stem cells (HSCs) were first identified half a century ago, their
differentiation roadmap has been extensively studied. The classical model of hematopoiesis …

The self-renewal capacity of multipotent haematopoietic stem cells (HSCs) supports blood
system homeostasis throughout life and underlies the curative capacity of clinical HSC …

Quiescence is a fundamental property that maintains hematopoietic stem cell (HSC) potency
throughout life. Quiescent HSCs are thought to rely on glycolysis for their energy, but the …

Adult tissue stem cells have a pivotal role in tissue maintenance and regeneration
throughout the lifespan of multicellular organisms. Loss of tissue homeostasis during post …

Many tissues and organ systems in metazoans have the intrinsic capacity to regenerate,
which is driven and maintained largely by tissue-resident somatic stem cell populations …

Metabolism has been studied mainly in cultured cells or at the level of whole tissues or
whole organisms in vivo. Consequently, our understanding of metabolic heterogeneity …