Abstract Microsampling, a reduced volume (< 50 μl) sampling method has successfully
gained attention at the International Conference on Harmonization (ICH) level. It has been …

Conventional sampling of biological fluids often involves a bulk quantity of samples that are
tedious to collect, deliver and process. Miniaturized sampling approaches have emerged as …

Information on the extent of drug exposure to mothers and infants during pregnancy and
lactation normally becomes available years after regulatory approval of a drug. Clinicians …

Background Breast milk transfer of first-line ART from mother to infant is not fully understood.
Objectives To determine the concentrations of lamivudine, emtricitabine and tenofovir in …

Conventional sampling techniques for clinical pharmacokinetic studies often require the
removal of large blood volumes from patients. This can result in a physiological or emotional …

The relative lack of information on medication use during breastfeeding is an ongoing
problem for health professionals and mothers alike. Most nursing mothers are prescribed …

Background. The antiretroviral drug efavirenz is widely used during breastfeeding.
Evaluating its safety requires an understanding of its breast milk pharmacokinetics, level of …

Objectives To evaluate antiretroviral drug concentrations in mothers and infants enrolled
under the Option B-Plus approach for the prevention of HIV mother-to-child transmission in …

Objectives To present the validation and clinical application of a LC–MS/MS method for the
quantification of lamivudine (3TC), emtricitabine (FTC) and tenofovir (TFV) in dried blood …

An overview of bioanalytical methods for the determination of environmental and
pharmaceutical contaminants in human milk is presented. The exposure of children to these …