Abstract CD4+/CD8+ DP thymocytes are a well-described T cell developmental stage within
the thymus. However, once differentiated, the CD4+ lineage or the CD8+ lineage is …

Most therapeutic monoclonal antibodies (mAbs) licensed for human use or in clinical
development are indicated for treatment of patients with cancer and inflammatory …

Animal models are an integral part of the drug development and evaluation process.
However, they are unsurprisingly imperfect reflections of humans, and the extent and nature …

Mature T lymphocytes expressing the αβ T cell receptor are generally classified as either
CD4+ or CD8+, based on the mutually exclusive expression of these two lymphocyte …

The expression of CD4 and CD8 co-receptors defines two distinct T cell populations with
specialized functions. While CD4+ T cells support and modulate immune responses through …

Since CD28 costimulation is critical for T-cell activation, there is great interest in CD28 as a
target for immuntherapeutic approaches. We show that stimulation of human CD4+ and …

Abstract Circulating CD4+ CD8+ double-positive (DP) T cells are associated with a variety of
disease states. However, unlike conventional T cells, the composition of this population is …

Costimulation of purified CD8+ T lymphocytes induces de novo expression of CD4,
suggesting a previously unrecognized function for this molecule in the immune response …

Biotherapeutics are a rapidly growing portion of the total pharmaceutical market accounting
for almost one-half of recent new drug approvals. A major portion of these approvals each …

Abstract CD4+ CD8+ double-positive (DP) T cells represent a minor subpopulation of T
lymphocytes found in the periphery of adult rats. In this study, we show that peripheral DP T …