The T cell receptor (TCR) complex is a naturally occurring antigen sensor that detects,
amplifies and coordinates cellular immune responses to epitopes derived from cell surface …

Gaussian accelerated molecular dynamics (GaMD) is a robust computational method for
simultaneous unconstrained enhanced sampling and free energy calculations of …

NAMD is a molecular dynamics program designed for high-performance simulations of very
large biological objects on CPU-and GPU-based architectures. NAMD offers scalable …

Genetic variability across the three major histocompatibility complex (MHC) class I genes
(human leukocyte antigen A [HLA-A],-B, and-C genes) may affect susceptibility to and …

Combined checkpoint blockade (eg, PD1/PD-L1) with traditional clinical therapies can be
hampered by side effects and low tumour-therapeutic outcome, hindering broad clinical …

Emerging data have shown that previously defined noncoding genomes might encode
peptides that bind human leukocyte antigen (HLA) as cryptic antigens to stimulate adaptive …

Adoptive cell therapy using engineered T cell receptors (TCRs) is a promising approach for
targeting cancer antigens, but tumor-reactive TCRs are often weakly responsive to their …

T cells are a critical part of the adaptive immune system that are able to distinguish between
healthy and unhealthy cells. Upon recognition of protein fragments (peptides), activated T …

AT cell receptor (TCR) mediates antigen-induced signaling through its associated CD3ε, δ,
γ, and ζ, but the contributions of different CD3 chains remain elusive. Using quantitative …

To identify disease-relevant T cell receptors (TCRs) with shared antigen specificity, we
analyzed 778,938 TCRβ chain sequences from 178 non-small cell lung cancer patients …