Aneuploidy, an abnormal chromosome composition, is a major contributor to cancer
development and progression and an important determinant of cancer therapeutic …

Methodological breakthroughs over the past four decades have repeatedly revolutionized
transcriptome profiling. Using RNA sequencing (RNA-seq), it has now become possible to …

Osteosarcoma is a highly aggressive cancer for which treatment has remained essentially
unchanged for more than 30 years. Osteosarcoma is characterized by widespread and …

Transcriptional enhanced associate domain (TEAD) transcription factors play important roles
during development, cell proliferation, regeneration, and tissue homeostasis. TEAD …

Osteosarcomas are sarcomas of the bone, derived from osteoblasts or their precursors, with
a high propensity to metastasize. Osteosarcoma is associated with massive genomic …

Osteosarcoma (OS) is the most common type of primary solid tumor that develops in bone.
Although standard chemotherapy has significantly improved long‐term survival over the past …

Yes-Associated Protein (YAP) and Transcriptional Co-activator with PDZ-binding Motif (TAZ)
have both emerged as important drivers of cancer progression and metastasis. YAP and …

Osteosarcoma is a disease with many complex genetic abnormalities but few well defined
genetic drivers of tumor initiation and evolution. The disease is diagnosed and defined …

Background Osteosarcomas are the most common primary malignant tumors of bone and
show multiple and complex genomic aberrations. miRNAs are non-coding RNAs capable of …

Background Resistance to cell death, a protective mechanism for removing damaged cells,
is a “Hallmark of Cancer” that is essential for cancer progression. Increasing attention to …