Monoclonal antibodies have revolutionized cancer therapy. However, delivery to tumor cells
in vivo is hampered by the large size (150 kDa) of conventional antibodies. The minimal …

Antibodies are versatile molecular binders with an established and growing role as
therapeutics. Computational approaches to developing and designing these molecules are …

Numerous antibodies that neutralize SARS-CoV-2 have been identified, and these generally
target either the receptor-binding domain (RBD) or the N-terminal domain (NTD) of the viral …

The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) pandemic continues,
with devasting consequences for human lives and the global economy,. The discovery and …

The adaptive immune system recognizes antigens via an immense array of antigen-binding
antibodies and T-cell receptors, the immune repertoire. The interrogation of immune …

The recombination between immunoglobulin (IG) gene segments determines an individual's
naïve antibody repertoire and, consequently,(auto) antigen recognition. Emerging evidence …

Vertebrate immune systems suppress viral infection using both innate restriction factors and
adaptive immunity. Viruses mutate to escape these defenses, driving hosts to counterevolve …

The vaccine-mediated elicitation of antibodies (Abs) capable of neutralizing diverse HIV-1
strains has been a long-standing goal. To understand how broadly neutralizing antibodies …

HIV-1 broadly neutralizing antibodies (bnAbs) require high levels of activation-induced
cytidine deaminase (AID)-catalyzed somatic mutations for optimal neutralization potency …

Discussion of the antibody repertoire usually emphasizes diversity, but a conspicuous
feature of the light chain repertoire is its lack of diversity. The diversity of reported allelic …