Drug-drug interactions (DDIs) arising from the perturbation of drug metabolising enzyme
activities represent both a clinical problem and a potential economic loss for the …

Microphysiological systems (MPS) consisting of multiple linked organ-on-a-chip (OoC)
components are highly promising tools with potential to provide more relevant in vitro to in …

Abstract The 2017 Guidance by US Food and Drug Administration (FDA) has recommended
the criteria to qualify for a Biopharmaceutical Classification System (BCS)‐based biowaiver …

Background Long-acting (LA) intramuscular cabotegravir and rilpivirine are prone to drug-
drug interactions (DDI). However, given the long dosing interval, the conduct of clinical DDIs …

Mathematical models, such as physiologically‐based pharmacokinetic models, are used to
predict, for example, drug disposition and toxicity. However, populations differ in the …

Highly specialized myrmecophagy (ant-and termite-eating) has independently evolved
multiple times in species of various mammalian orders and represents a textbook example …

Crohn's disease affects the mucosal layer of the intestine, predominantly ileum and colon
segments, with the potential to affect the expression of intestinal enzymes and transporters …

Characterising the small intestine absorptive membrane is essential to enable prediction of
the systemic exposure of oral formulations. In particular, the ontogeny of key intestinal Drug …

The applications of translational modeling of local drug concentrations in various organs
had a sharp increase over the last decade. These are part of the model‐informed drug …

ABC transporters (ATP‐binding cassette transporter) traffic drugs and their metabolites
across membranes, making ABC transporter expression levels a key factor regulating local …