Although dementia has been described in ancient texts over many centuries (eg,“Be kind to
your father, even if his mind fail him.”–Old Testament: Sirach 3: 12), our knowledge of its …

Possession of the ε4 allele of apolipoprotein E (APOE) is the primary genetic risk factor for
the sporadic form of Alzheimer's disease (AD). While researchers have extensively …

The goal of this review is to discuss how behavioral tests in mice relate to the pathological
and neuropsychological features seen in human Alzheimer's disease (AD), and present a …

The concept of reserve has been proposed to account for the disjunction between the
degree of brain damage and its clinical outcome. This paper attempts to produce a coherent …

The neuropsychologic test battery from the Uniform Data Set (UDS) of the Alzheimer's
Disease Centers (ADC) program of the National Institute on Aging consists of brief measures …

APOE-ε4 is best known as a risk factor for Alzheimer's disease (AD). Consequently, there is
considerable research interest in understanding whether APOE-ε4 influences cognition in …

The results of studies from the Washington University Alzheimer Disease (AD) Research
Center and those from other centers and investigators regarding the neuropathologic …

Why are some people more mentally able than others? In an authoritative, critical and
intergrated series of review essays Professor Ian Deary inquires after the cognitive and …

The ε4 allele of the apolipoprotein E (APOE) gene is a known risk factor for Alzheimer's
disease and may also affect cognitive performance in normal aging. Evidence of the …

Subjects in the preclinical stages of Alzheimer's disease (AD) typically record
neuropsychological performance between that of healthy older individuals and demented …