Cell signaling plays a key role in the development of all multicellular organisms. Numerous
studies have established the importance of Hedgehog signaling in a wide variety of …

▪ Abstract Embryological and genetic studies of mouse, bird, zebrafish, and frog embryos are
providing new insights into the regulatory functions of the myogenic regulatory factors …

The sequencing of the zebrafish genome should be completed by the end of 2002. Direct
assignment of function on the basis of this information would be facilitated by the …

In vertebrates, Hedgehog (Hh) signaling initiated in primary cilia activates the membrane
protein Smoothened (Smo) and leads to activation of Gli proteins, the transcriptional …

Motile cilia induce fluid movement through their rhythmic beating activity. In mammals, the
transcription factor Foxj1 has been implicated in motile cilia formation. Here we show that a …

The vertebrate zinc finger genes of the Gli family are homologs of the Drosophila gene
cubitus interruptus. In frog embryos, Gli1 is expressed transiently in the prospective floor …

Although the framework of the Hedgehog (Hh) signaling pathway is evolutionarily
conserved, recent studies indicate that fundamental differences exist between Drosophila …

† Department of Genetics Harvard Medical School ferentiated in the so-called “progress
zone,” while condensation initiates in proximal limb regions, so that the Boston …

Members of the Hedgebog family of signaling molecules mediate many important short-and
long-range patterning processes during invertebrate and vertebrate development. In the fly …

The developmentally important hedgehog (Hh) pathway is activated by binding of Hh to
patched (Ptch1), releasing smoothened (Smo) and the downstream transcription factor …