Outer membrane vesicles secreted by gram-negative bacteria play an important role in
bacterial physiology as well as in virulence and host–pathogen interaction. Isolated vesicles …

Francisella tularensis is the causative agent of the acute disease tularemia. Due to its
extreme infectivity and ability to cause disease upon inhalation, F. tularensis has been …

Cancer therapy is undergoing a paradigm shift toward immunotherapy focusing on various
approaches to activate the host immune system. As research to identify appropriate immune …

Francisella tularensis is a Gram-negative intracellular pathogen and the causative agent of
the disease tularemia. Inhalation of as few as 10 bacteria is sufficient to cause severe …

In recent years, several emerging zoonotic vector-borne infections with potential impact on
human health have been identified in Europe, including tularaemia, caused by Francisella …

Complement receptor 3 (CR3, CD11b/CD18) is a major macrophage phagocytic receptor.
The biochemical pathways through which CR3 regulates immunologic responses have not …

Francisella tularensis is a Gram-negative, facultative intracellular bacterium, causing a
severe disease called tularemia. It secretes unusually shaped nanotubular outer membrane …

Francisella tularensis is an intracellular Gram-negative bacterium that causes life-
threatening tularemia. Although the prevalence of natural infection is low, F. tularensis …

Francisella tularensis is the causative agent of tularemia and a Tier I bioterrorism agent. In
the 1900s, several vaccines were developed against tularemia including the killed “Foshay” …

Our understanding of the virulence and pathogenesis of Francisella spp. has significantly
advanced in recent years, including a new understanding that this organism can form …