Regulation of placental development and its impact on fetal growth—new insights from mouse models

L Woods, V Perez-Garcia, M Hemberger - Frontiers in endocrinology, 2018 - frontiersin.org
The placenta is the chief regulator of nutrient supply to the growing embryo during gestation.
As such, adequate placental function is instrumental for developmental progression …

The role of cellular senescence in female reproductive aging and the potential for senotherapeutic interventions

L Secomandi, M Borghesan, M Velarde… - Human reproduction …, 2022 - academic.oup.com
BACKGROUND Advanced maternal age is associated with decreased oocyte quantity and
quality as well as uterine and placental dysfunctions. These changes lead to infertility …

[HTML][HTML] Unveiling uterine aging: much more to learn

Y Wu, M Li, J Zhang, S Wang - Ageing Research Reviews, 2023 - Elsevier
Uterine aging is an important factor that impacts fertility, reproductive health, and uterus-
related diseases; however, it remains poorly explored. Functionally, these disturbances …

Uterine Aging and Reproduction: Dealing with a Puzzle Biologic Topic

A Tinelli, M Andjić, A Morciano, G Pecorella… - International Journal of …, 2023 - mdpi.com
Uterine aging is the process of the senescence of uterine tissue, observed in all middle-
aged mammals. Since the aging-related changes in the uterus are associated with infertility …

Aging promotes accumulation of senescent and multiciliated cells in human endometrial epithelium

M Loid, D Obukhova, K Kask, A Apostolov… - Human …, 2024 - academic.oup.com
STUDY QUESTION What changes occur in the endometrium during aging, and do they
impact fertility? SUMMARY ANSWER Both the transcriptome and cellular composition of …

[HTML][HTML] Underlying mechanisms and treatment of cellular senescence-induced biological barrier interruption and related diseases

R Sun, J Feng, J Wang - Aging and Disease, 2024 - ncbi.nlm.nih.gov
Given its increasing prevalence, aging is of great concern to researchers worldwide. Cellular
senescence is a physiological or pathological cellular state caused by aging and a …

Mechanisms of endometrial aging: lessons from natural conceptions and assisted reproductive technology cycles

A Chemerinski, J Garcia de Paredes… - Frontiers in …, 2024 - frontiersin.org
Until recently, the study of age-related decline in fertility has focused primarily on the ovary;
depletion of the finite pool of oocytes and increases in meiotic errors leading to oocyte …

Epigenetic control of embryo–uterine crosstalk at peri-implantation

S Kong, C Zhou, H Bao, Z Ni, M Liu, B He… - Cellular and Molecular …, 2019 - Springer
Embryo implantation is one of the pivotal steps during mammalian pregnancy, since the
quality of embryo implantation determines the outcome of ongoing pregnancy and fetal …

[HTML][HTML] Phytosterols in mountain cultivated ginseng, as master healthy ageing dietary supplement, activates steroid signaling in ageing Drosophila melanogaster

J Liu, R Ma, B Fu, P Yang, L Zhang, C Zhang… - Experimental …, 2024 - Elsevier
Mountain cultivated ginseng (MCG) is planted in mountain forests to simulate traditional wild
ginseng; therefore, it has a greater pharmacological effect than cultivated ginseng (CG) in …

The activation of cGAS‐STING pathway causes abnormal uterine receptivity in aged mice

ST Chen, WW Shi, F Ran, CK Liu, HN Luo, LJ Wu… - Aging …, 2024 - Wiley Online Library
Maternal age is one of the most important factors affecting the success of maternal
pregnancy. Uterine aging is the leading cause of pregnancy failure in older women …