Background Infertility is a common reproductive disorder, with male factor infertility
accounting for approximately half of all cases. Taking a paternal perceptive, recent research …

Over the last decade, the number of cancer survivors has increased thanks to progress in
diagnosis and treatment. Cancer treatments are often accompanied by adverse side effects …

STUDY QUESTION Do paternal exposures to folic acid deficient (FD), and/or folic acid
supplemented (FS) diets, throughout germ cell development adversely affect male germ …

Objective To determine the consequences of adjuvant testicular germ cell tumor treatment
(TGCT) on sperm characteristics and sperm DNA, and to evaluate the predictors of sperm …

Introduction: There are significant rates of attrition in drug development. A number of
compounds fail to progress past preclinical development due to limited tools that accurately …

Cisplatin is an effective antineoplastic drug that is usually used to treat a number of different
types of cancer in the clinic. One of the most notable side effects of cisplatin use is infertility …

The genetic effects of human exposure to anticancer drugs remain poorly understood. To
establish whether exposure to anticancer drugs can result not only in mutation induction in …

Background The potential that adolescent chemotherapy can impact the epigenetic
programming of the germ line to influence later life adult fertility and promote epigenetic …

Testicular cancer (TC) is one of the most treatable of all malignancies and the management
of the quality of life of these patients is increasingly important, especially with regard to their …

Cytotoxic anticancer chemotherapy affects pituitary–testicular hormonal axis in humans and
in animals. This study investigated the effects on Leydig cells of three cycles of bleomycin …