The Sox2 transcription factor, encoded by a gene conserved in animal evolution, has
become widely known because of its functional relevance for stem cells. In the developing …

Interaction with the world around us requires extracting meaningful signals to guide
behavior. Each of the six mammalian senses (olfaction, vision, somatosensation, hearing …

Although de novo mutations (DNMs) are known to increase an individual's risk of congenital
defects, DNMs have not been fully explored regarding orofacial clefts (OFCs), one of the …

SOX2 is essential for maintaining neurosensory stem cell properties, although its
involvement in the early neurosensory development of cranial placodes remains unclear. To …

Depression is a neuropsychiatric disorder and has intrauterine developmental origins. This
study aimed to confirm the depression susceptibility in offspring rats induced by prenatal …

Neuronal development in the inner ear is initiated by expression of the proneural basic Helix-
Loop-Helix (bHLH) transcription factor Neurogenin1 that specifies neuronal precursors in …

SOX2 and SOX15 are Sox family transcription factors enriched in embryonic stem cells
(ESCs). The role of SOX2 in activating gene expression programs essential for stem cell self …

Visual system development involves the formation of neuronal projections connecting the
retina to the thalamic dorso-lateral geniculate nucleus (dLGN) and the thalamus to the visual …

Opsin 3 (Opn3) is highly expressed in the adult brain, however, information for spatial and
temporal expression patterns during embryogenesis is significantly lacking. Here, an Opn3 …

The vomeronasal organ (VNO) is sensory organ located in the ventral region of the nasal
cavity in rodents. The VNO develops from the olfactory placode during the secondary …