Mitophagy mediated by the recessive Parkinson's disease genes PINK1 and Parkin
responds to mitochondrial damage to preserve mitochondrial function. In the pathway …

The sub-compartmentalization of cellular processes is especially important in highly
polarized cells such as neurons, as their function rely on their complex morphology. The …

Simple Summary Mitochondria-shaping proteins are pivotal in maintaining the dynamic
structure of mitochondria, which constantly undergo fusion and fission. This dynamic …

Mitochondria are often referred to as the “powerhouse” of the cell. However, this organelle
has many more functions than simply satisfying the cells' metabolic needs. Mitochondria are …

A central role in mitochondrial quality control is played by the Parkinson-related
mitochondrial kinase PINK1, whose mRNA is transported in neurons by mitochondrial hitch …

Neurons integrate perception, motor, and cognitive functions, relying heavily on
mitochondria for ATP production to support axonal transport, synaptic activity, and …

Mitochondria are dynamic organelles that can adjust and respond to different stimuli within a
cell. This plastic ability allows them to effectively coordinate several cellular functions in cells …

Mitochondria are critical organelles that continually remodel to carry out their many cellular
functions. This remodeling is particularly important in neurons due to the specialized shape …