Multipotent blood progenitor cells enter the thymus and begin a protracted differentiation
process in which they gradually acquire T-cell characteristics while shedding their legacy of …

PU. 1 directs the hematopoietic stem cell to the lymphoid-myeloid progenitor (LMP) and
interacts with GATA-binding protein 1 to inhibit commitment to the megakaryocyte-erythroid …

The high mobility group (HMG) transcription factor TCF-1 is essential for early T cell
development. Although in vitro biochemical assays suggest that HMG proteins can serve as …

T and B cells share a common somatic gene rearrangement mechanism for assembling the
genes that code for their antigen receptors; they also have developmental pathways with …

The first checkpoint in T cell development, β selection, has remained incompletely
characterized for lack of specific surface markers. We show that CD27 is upregulated in DN3 …

In recent years, investigators have made great progress in delineating developmental
pathways of several lymphoid and myeloid lineages and in identifying transcription factors …

Transcription factors normally regulate gene expression through their action at sites where
they bind to DNA. However, the balance of activating and repressive functions that a …

Multipotent progenitor cells confirm their T cell–lineage identity in the CD4–CD8–double-
negative (DN) pro-T cell DN2 stages, when expression of the essential transcription factor …

PU. 1 is an ETS-family transcription factor that plays a broad range of roles in
hematopoiesis. A direct regulator of myeloid, dendritic-cell, and B cell functional programs …

The zinc finger transcription factor, Bcl11b, is expressed in T cells and group 2 innate
lymphoid cells (ILC2s) among hematopoietic cells. In early T-lineage cells, Bcl11b directly …