Enterovirus D68 and acute flaccid myelitis—evaluating the evidence for causality

K Messacar, EJ Asturias, AM Hixon… - The Lancet Infectious …, 2018 - thelancet.com
Increased circulation of enterovirus D68 in 2014 and 2016 temporally and geographically
coincided with increases in cases of acute flaccid myelitis, an uncommon condition of …

Twenty-nine cases of enterovirus-D68–associated acute flaccid myelitis in Europe 2016: a case series and epidemiologic overview

M Knoester, J Helfferich, R Poelman… - The Pediatric …, 2019 - journals.lww.com
Background: Enterovirus-D68 (EV-D68) is a respiratory virus within the genus Enterovirus
and the family of Picornaviridae. Genetically, it is closely related to rhinovirus that replicates …

[HTML][HTML] Re-emergence of enterovirus D68 in Europe after easing the COVID-19 lockdown, September 2021

KSM Benschop, J Albert, A Anton, C Andrés… - …, 2021 - eurosurveillance.org
We report a rapid increase in enterovirus D68 (EV-D68) infections, with 139 cases reported
from eight European countries between 31 July and 14 October 2021. This upsurge is in line …

A mouse model of paralytic myelitis caused by enterovirus D68

AM Hixon, G Yu, JS Leser, S Yagi, P Clarke… - PLoS …, 2017 - journals.plos.org
In 2014, the United States experienced an epidemic of acute flaccid myelitis (AFM) cases in
children coincident with a nationwide outbreak of enterovirus D68 (EV-D68) respiratory …

Pan-viral serology implicates enteroviruses in acute flaccid myelitis

RD Schubert, IA Hawes, PS Ramachandran… - Nature medicine, 2019 - nature.com
Abstract Since 2012, the United States of America has experienced a biennial spike in
pediatric acute flaccid myelitis (AFM),,,,–. Epidemiologic evidence suggests non-polio …

[HTML][HTML] The association between acute flaccid myelitis (AFM) and Enterovirus D68 (EV-D68)–what is the evidence for causation?

A Dyda, S Stelzer-Braid, D Adam… - …, 2018 - eurosurveillance.org
Background Enterovirus D68 (EV-D68) has historically been a sporadic disease, causing
occasional small outbreaks of generally mild infection. In recent years, there has been …

Circulation of non-polio enteroviruses in 24 EU and EEA countries between 2015 and 2017: a retrospective surveillance study

L Bubba, EK Broberg, A Jasir, P Simmonds… - The Lancet Infectious …, 2020 - thelancet.com
Background Enteroviruses can cause severe infections, especially in young children. Non-
polio enterovirus infections are not notifiable in most countries in the EU and European …

Clinical features of acute flaccid myelitis temporally associated with an enterovirus D68 outbreak: results of a nationwide survey of acute flaccid paralysis in Japan …

PF Chong, R Kira, H Mori, A Okumura… - Clinical Infectious …, 2018 - academic.oup.com
Background Acute flaccid myelitis (AFM) is an acute flaccid paralysis syndrome with spinal
motor neuron involvement of unknown etiology. We investigated the characteristics and …

Enteroviruses remodel autophagic trafficking through regulation of host SNARE proteins to promote virus replication and cell exit

AK Corona, HM Saulsbery, AFC Velazquez… - Cell reports, 2018 - cell.com
Summary Enterovirus D68 (EV-D68) is a medically important respiratory plus-strand RNA
virus of children that has been linked to acute flaccid myelitis. We have determined that EV …

Causes and clinical features of childhood encephalitis: a multicenter, prospective cohort study

PN Britton, RC Dale, CC Blyth, JE Clark… - Clinical Infectious …, 2020 - academic.oup.com
Background We aimed to determine the contemporary causes, clinical features, and short-
term outcome of encephalitis in Australian children. Methods We prospectively identified …