Recurrent topics in mass spectrometry-based metabolomics and lipidomics—standardization, coverage, and throughput

E Rampler, YE Abiead, H Schoeny, M Rusz… - Analytical …, 2020 - ACS Publications
We have come a long way in the last years of developing analytical strategies in
metabolomics. We have seen huge progress in tackling multiplatform measurement, data …

Recommendations for good practice in MS-based lipidomics

HC Köfeler, R Ahrends, ES Baker, K Ekroos, X Han… - Journal of lipid …, 2021 - ASBMB
In the last 2 decades, lipidomics has become one of the fastest expanding scientific
disciplines in biomedical research. With an increasing number of new research groups to …

Software tools, databases and resources in metabolomics: updates from 2018 to 2019

K O'Shea, BB Misra - Metabolomics, 2020 - Springer
Metabolomics has evolved as a discipline from a discovery and functional genomics tool,
and is now a cornerstone in the era of big data-driven precision medicine. Sample …

LipidCreator workbench to probe the lipidomic landscape

B Peng, D Kopczynski, BS Pratt, CS Ejsing… - Nature …, 2020 - nature.com
Mass spectrometry (MS)-based targeted lipidomics enables the robust quantification of
selected lipids under various biological conditions but comprehensive software tools to …

On-tissue dataset-dependent MALDI-TIMS-MS2 bioimaging

S Heuckeroth, A Behrens, C Wolf, A Fütterer… - Nature …, 2023 - nature.com
Trapped ion mobility spectrometry (TIMS) adds an additional separation dimension to mass
spectrometry (MS) imaging, however, the lack of fragmentation spectra (MS2) impedes …

Platelet lipid metabolism in vascular thrombo-inflammation

MC Manke, R Ahrends, O Borst - Pharmacology & Therapeutics, 2022 - Elsevier
The function of platelets–and thereby the balance between thrombosis and hemostasis–
critically depends on their lipid composition. At the same time, platelets are capable of …

The lipidomics reporting checklist a framework for transparency of lipidomic experiments and repurposing resource data

D Kopczynski, CS Ejsing, JG McDonald, T Bamba… - Journal of lipid …, 2024 - jlr.org
The rapid increase in lipidomic studies has led to a collaborative effort within the community
to establish standards and criteria for producing, documenting, and disseminating data …

Tricky isomers—the evolution of analytical strategies to characterize plasmalogens and plasmanyl ether lipids

J Koch, K Watschinger, ER Werner… - Frontiers in Cell and …, 2022 - frontiersin.org
Typically, glycerophospholipids are represented with two esterified fatty acids. However, by
up to 20%, a significant proportion of this lipid class carries an ether-linked fatty alcohol side …

[HTML][HTML] Nanoscale separations: Recent achievements

C Aydoğan, B Beltekin, H Aslan, F Yılmaz… - Journal of …, 2022 - Elsevier
Nanoscale separation techniques (Capillary/nano-LC, CE, CEC and Chip based
LC/CE/CEC) present a prospective trend in modern analytical chemistry due to allowing …

Validation of a multiplexed and targeted lipidomics assay for accurate quantification of lipidomes

NR Zhang, NG Hatcher, K Ekroos, K Kedia… - Journal of Lipid …, 2022 - ASBMB
A major challenge of lipidomics is to determine and quantify the precise content of complex
lipidomes to the exact lipid molecular species. Often, multiple methods are needed to …