Infections with drug-resistant bacteria have become one of the greatest public health
challenges, and K. pneumoniae is among the top six drug-resistant bacteria. K. pneumoniae …

Host‐directed therapies (HDTs) have emerged as a promising strategy to combat viral
infections by modifying host factors and immune responses to restrict viral replication and …

Background Itaconate, a crucial immunometabolite, plays a critical role in linking immune
and metabolic functions to influence host defense and inflammation. Due to its polar …

Protozoan parasite infections, particularly leishmaniasis, present significant public health
challenges in tropical and subtropical regions, affecting socio-economic status and growth …

Background and Objectives: Klebsiella pneumoniae is a major nosocomial pathogen with a
remarkable ability to develop resistance to multiple antibiotics, posing significant treatment …

Antiviral drugs have classically been developed by directly disrupting the functions of viral
proteins. However, this strategy has been largely unsuccessful due to the rapid generation …

Background Genome streamlining, the process by which genomes become smaller and
encode fewer genes over time, is a common phenomenon among pathogenic bacteria. This …