Ocular blood flow as a clinical observation: Value, limitations and data analysis

A Harris, G Guidoboni, B Siesky, S Mathew… - Progress in retinal and …, 2020 - Elsevier
Alterations in ocular blood flow have been identified as important risk factors for the onset
and progression of numerous diseases of the eye. In particular, several population-based …

Neurodegenerative disorders of the eye and of the brain: a perspective on their fluid-dynamical connections and the potential of mechanism-driven modeling

G Guidoboni, R Sacco, M Szopos, L Sala… - Frontiers in …, 2020 - frontiersin.org
Neurodegenerative disorders (NDD) such as Alzheimer's and Parkinson's diseases are
significant causes of morbidity and mortality worldwide. The pathophysiology of NDD is still …

Advancing treatment of retinal disease through in silico trials

RJ Hernandez, PA Roberts… - Progress in Biomedical …, 2023 - iopscience.iop.org
Treating retinal diseases to prevent sight loss is an increasingly important challenge. Thanks
to the configuration of the eye, the retina can be examined relatively easily in situ. Owing to …

Physics-based modeling of age-related macular degeneration—a theoretical approach to quantify retinal and choroidal contributions to macular oxygenation

ACV Vercellin, A Harris, G Chiaravalli, R Sacco… - Mathematical …, 2021 - Elsevier
We developed a mathematical model to characterize how macular oxygenation may be
affected by abnormalities in the retinal and choroidal oxygen supplies. The macular region is …

Analysis of a Multiscale Interface Problem Based on the Coupling of Partial and Ordinary Differential Equations to Model Tissue Perfusion

L Bociu, M Broussard, G Guidoboni… - Multiscale Modeling & …, 2025 - SIAM
In biomechanics, local phenomena, such as tissue perfusion, are strictly related to the global
features of the surrounding blood circulation. In this paper, we propose a heterogeneous …

Validation of hydraulic mechanism during blowout trauma of human orbit depending on the method of load application

MA Zmuda Trzebiatowski, P Kłosowski… - Applied Bionics and …, 2021 - Wiley Online Library
The more we know about mechanisms of the human orbital blowout type of trauma, the
better we will be able to prevent them in the future. As long as the buckling mechanism's …

Retinal Venous Vulnerability in Primary Open Angle Glaucoma: The Combined Effects of Intraocular Pressure and Blood Pressure with Application to the Thessaloniki …

R Rai, G Guidoboni, CK Wikle, F Topouzis, B Siesky… - La Matematica, 2024 - Springer
Primary open angle glaucoma (POAG) is a leading cause of irreversible blindness with risk
factors including elevated intraocular pressure (IOP), and both high and low blood pressure …

Spreading mechanics and differentiation of astrocytes during retinal development

TL Stepien, TW Secomb - Journal of Theoretical Biology, 2022 - Elsevier
The retinal vasculature supplies oxygen to the inner layers of the retina, the light-sensitive
tissue in the eye. During development, formation of the retinal vasculature depends on prior …

[PDF][PDF] Research Article Validation of Hydraulic Mechanism during Blowout Trauma of Human Orbit Depending on the Method of Load Application

MAZ Trzebiatowski, P Kłosowski, A Skorek, K Żerdzicki… - 2021 - academia.edu
The more we know about mechanisms of the human orbital blowout type of trauma, the
better we will be able to prevent them in the future. As long as the buckling mechanism's …

A loosely-coupled scheme for cardiac electro fluid structure interaction

MG Gabriel - 2020 - politesi.polimi.it
The purpose of this work is to propose a new Loosely-Coupled Scheme for Cardiac Electro
Fluid Structure Interaction Problems. Hence, we review some of the most critical issues in …