Single-cell and bulk RNA-sequence identified fibroblasts signature and CD8+ T-cell-fibroblast subtype predicting prognosis and immune therapeutic response of …

J Li, Z Kong, Y Qi, W Wang, Q Su… - … Journal of Surgery, 2024 - journals.lww.com
Background: Cancer-associated fibroblasts (CAFs) are found in primary and advanced
tumours. They are primarily involved in tumour progression through complex mechanisms …

Fibroblast activation protein: pivoting cancer/chemotherapeutic insight towards heart failure

J Gehris, C Ervin, C Hawkins, S Womack… - Biochemical …, 2024 - Elsevier
An important mechanism for cancer progression is degradation of the extracellular matrix
(ECM) which is accompanied by the emergence and proliferation of an activated fibroblast …

Targeting allosteric binding site in methylenetetrahydrofolate dehydrogenase 2 (MTHFD2) to identify natural product inhibitors via structure-based computational …

N Rana, D Patel, M Parmar, N Mukherjee, PC Jha… - Scientific Reports, 2023 - nature.com
Cancer has been viewed as one of the deadliest diseases worldwide. Among various types
of cancer, breast cancer is the most common type of cancer in women …

Potential signature therapeutic biomarkers TOP2A, MAD2L1, and CDK1 in colorectal cancer: a systems biomedicine-based approach

P Priyamvada, S Ramaiah - Biochemical Genetics, 2024 - Springer
Colorectal cancer is the third deadliest and fourth most diagnosed cancer. It is
heterogeneously driven by varied mutations and mutagens, and thus, it is challenging for …

FN1, a reliable prognostic biomarker for thyroid cancer, is associated with tumor immunity and an unfavorable prognosis

H Pan, Z Luo, F Lin, J Zhang, T Xiong… - Oncology …, 2024 - spandidos-publications.com
Thyroid cancer (THCA) is a malignant tumor that affects the endocrine system. At present, an
effective treatment for THCA remains elusive, particularly for medullary carcinoma and …

Consolidated knowledge-guided computational pipeline for therapeutic intervention against bacterial biofilms-a review

R Debroy, S Ramaiah - Biofouling, 2023 - Taylor & Francis
Biofilm-associated bacterial infections attributed to multifactorial antimicrobial resistance
have caused worldwide challenges in formulating successful treatment strategies. In search …

A Comprehensive Pan-Cancer Analysis of Cytochrome C Oxidase Assembly Factor 1 (COA1) Reveals Instrumental Role of Mitochondrial Protein Assembly in Cancer …

S Ghosh, D Goswami, R Dutta, D Ghatak… - Cell Biochemistry and …, 2024 - Springer
Cytochrome c oxidase assembly factor 1 (COA1), a mitochondrial respiratory chain complex
assembly factor protein of inner mitochondrial membrane (IMM), is involved in translating …

Transcriptomic, mutational and structural bioinformatics approaches to explore the therapeutic role of FAP in predominant cancer types

G Ashok, AF AlAsmari, F AlAsmari, P Livingstone… - Discover Oncology, 2024 - Springer
Fibroblast activating protein (FAP) is a cell surface marker of cancer-associated fibroblasts
with a distinct pro-tumorigenic role. The present study analyzed the pan-cancer expression; …

Unravelling the molecular mechanistic pathway underlying the anticancer effects of kaempferol in colorectal cancer: a reverse pharmacology network approach

P Priyamvada, G Ashok, T Joshi, S Anbarasu… - Molecular Diversity, 2024 - Springer
Colorectal cancer (CRC) is the third most diagnosed and highly fatal malignancy, presenting
serious health concerns worldwide. The search for an effective cure for CRC is challenging …

Elucidating the molecular role of MUC5B in progressive lung adenocarcinoma: Prospects for early diagnosis

G Ashok, A Soundararajan, A Anbarasu… - Journal of Molecular …, 2024 - Wiley Online Library
Gel‐forming mucin MUC5B is significantly deregulated in lung adenocarcinoma (LUAD),
however, its role in tumor progression is not yet clearly understood. Here, we used an …