It has been acknowledged that more women suffer from adverse effects of drugs than men
globally. A group of drugs targeting serotonin [5-hydroxytryptamine](5-HT) binding G-protein …

Background Asthma affects 3% of the global population, leading to over 0.25 million deaths.
Due to its complexity, asthma is difficult to cure or prevent, and current therapies have …

Renal vasculature, which is highly innervated by sympathetic fibers, contributes to
cardiovascular homeostasis. This renal sympathetic outflow is inhibited by 5-HT in …

Using several 5-hydroxytryptamine (5-HT) agonists and antagonists, we attempted to
characterize the receptor subtypes involved in the contractile response to 5-HT in the in situ …

The aim of the present study was to elucidate the pathogenic role of endogenous 5-HT in
pancreatitis. Injections of cerulein at hourly intervals caused edematous pancreatitis in mice …

We attempted to characterize the 5-hydroxytryptamine (5-HT) receptor type/subtype and
mediator mechanisms involved in the contractile effects of 5-HT in the in situ autoperfused …

Publisher Summary This chapter discusses the various receptor mediated events in the
microcirculation focusing on the various kinds of receptors. Epinephrine (Epi) and …

We evaluated the renal vascular effects of serotonin in Nω-Nitro-l-arginine-hypertensive rats
(L-NAME, 30mg/kg/day, administered over 21days in drinking water), a model of systemic …

The aim of this study was to determine whether orally sarpogrelate (selective 5-HT 2
antagonist) treatment (30 mg/kg/day; 14 days) could modify 5-HT renal vasoconstrictor …

In this work we studied the responses and receptors involved in the effects of intra-arterial 5-
hydroxytryptamine (5-HT) in the in situ autoperfused hindquarters of spontaneously …