Metabolomic epidemiology offers insights into disease aetiology
Metabolomic epidemiology is the high-throughput study of the relationship between
metabolites and health-related traits. This emerging and rapidly growing field has improved …
metabolites and health-related traits. This emerging and rapidly growing field has improved …
Metabolomics and multi-omics integration: a survey of computational methods and resources
As researchers are increasingly able to collect data on a large scale from multiple clinical
and omics modalities, multi-omics integration is becoming a critical component of …
and omics modalities, multi-omics integration is becoming a critical component of …
Metabolomic profiling reveals extensive adrenal suppression due to inhaled corticosteroid therapy in asthma
The application of large-scale metabolomic profiling provides new opportunities for realizing
the potential of omics-based precision medicine for asthma. By leveraging data from over …
the potential of omics-based precision medicine for asthma. By leveraging data from over …
Ambient PM2. 5 species and ultrafine particle exposure and their differential metabolomic signatures
Background The metabolomic signatures of short-and long-term exposure to PM 2.5 have
been reported and linked to inflammation and oxidative stress. However, little is known …
been reported and linked to inflammation and oxidative stress. However, little is known …
Integrated-omics endotyping of infants with rhinovirus bronchiolitis and risk of childhood asthma
Y Raita, CA Camargo Jr, YA Bochkov… - Journal of Allergy and …, 2021 - Elsevier
Background Young children with rhinovirus (RV) infection—particularly bronchiolitis—are at
high risk for developing childhood asthma. Emerging evidence suggests clinical …
high risk for developing childhood asthma. Emerging evidence suggests clinical …
Genomic predictors of asthma phenotypes and treatment response
N Hernandez-Pacheco, M Pino-Yanes… - Frontiers in …, 2019 - frontiersin.org
Asthma is a complex respiratory disease considered as the most common chronic condition
in children. A large genetic contribution to asthma susceptibility is predicted by the clustering …
in children. A large genetic contribution to asthma susceptibility is predicted by the clustering …
Characteristics and mechanisms of a sphingolipid-associated childhood asthma endotype
D Rago, CET Pedersen, M Huang, RS Kelly… - American journal of …, 2021 - atsjournals.org
Rationale: A link among sphingolipids, 17q21 genetic variants, and childhood asthma has
been suggested, but the underlying mechanisms and characteristics of such an asthma …
been suggested, but the underlying mechanisms and characteristics of such an asthma …
Air pollution, metabolites and respiratory health across the life-course
Previous studies have explored the relationships of air pollution and metabolic profiles with
lung function. However, the metabolites linking air pollution and lung function and the …
lung function. However, the metabolites linking air pollution and lung function and the …
Severe asthma phenotypes and endotypes
I Agache - Seminars in immunology, 2019 - Elsevier
Current management of severe asthma relying either on guidelines (bulk approach) or on
disease phenotypes (stratified approach) did not improve the burden of the disease. Several …
disease phenotypes (stratified approach) did not improve the burden of the disease. Several …
Integrative metabolomics to identify molecular signatures of responses to vaccines and infections
Approaches to the identification of metabolites have progressed from early biochemical
pathway evaluation to modern high-dimensional metabolomics, a powerful tool to identify …
pathway evaluation to modern high-dimensional metabolomics, a powerful tool to identify …