Adipose tissue, colloquially known as" fat," is an extraordinarily flexible and heterogeneous
organ. While historically viewed as a passive site for energy storage, we now appreciate that …

In mammals, the white adipocyte is a cell type that is specialized for storage of energy (in the
form of triacylglycerols) and for energy mobilization (as fatty acids). White adipocyte …

Brown and beige adipocytes are mitochondria-enriched cells capable of dissipating energy
in the form of heat. These thermogenic fat cells were originally considered to function solely …

Adipose tissues display a remarkable ability to adapt to the dietary status. Here, we have
applied single-nucleus RNA-seq to map the plasticity of mouse epididymal white adipose …

Obesity is a chronic and progressive process affecting whole-body energy balance and is
associated with comorbidity development. In addition to increased fat mass, obesity induces …

Adipose tissues dynamically remodel their cellular composition in response to external cues
by stimulating beige adipocyte biogenesis; however, the developmental origin and …

Rather than serving as a mere onlooker, adipose tissue is a complex endocrine organ and
active participant in disease initiation and progression. Disruptions of biological processes …

Background The diminished glucose lowering effect of insulin in obesity, called “insulin
resistance,” is associated with glucose intolerance, type 2 diabetes, and other serious …

The coordination of nutrient sensing, delivery, uptake and utilization is essential for
maintaining cellular, tissue and whole-body homeostasis. Such synchronization can be …

Visceral adiposity is a risk factor for severe COVID-19, and a link between adipose tissue
infection and disease progression has been proposed. Here we demonstrate that SARS …