Duchenne muscular dystrophy (DMD) is a devastating disease featuring skeletal muscle
wasting, respiratory insufficiency, and cardiomyopathy. Historically, respiratory failure has …

The thrombospondin (Thbs) family of secreted matricellular proteins are stress-and injury-
induced mediators of cellular attachment dynamics and extracellular matrix protein …

Thrombospondins (TSPs) are multidomain, secreted proteins that associate with cell
surfaces and extracellular matrix. In mammals, there is a large body of data on functional …

Background: Acute kidney injury (AKI) is a short-term life-threatening condition that, if
survived, can lead to renal insufficiency and development of chronic kidney disease. The …

S-palmitoylation is a reversible lipid modification catalyzed by 23 S-acyltransferases with a
conserved zinc finger aspartate-histidine-histidine-cysteine (zDHHC) domain that facilitates …

Production and release of natriuretic peptides by the stressed heart reduce cardiac workload
by promoting vasodilation, natriuresis, and diuresis, which has been leveraged in the recent …

Abstract Thrombospondin-4 (TSP-4) attracted renewed attention recently as a result of
assignment of new functions to this matricellular protein in cardiovascular, muscular, and …

Thrombospondins (Thbs) are a family of five secreted matricellular glycoproteins in
vertebrates that broadly affect cell-matrix interaction. While Thbs4 is known to protect striated …

Thrombospondins (TSPs) are multidomain, calcium-binding glycoproteins that have wide-
ranging roles in vertebrates in cell interactions, extracellular matrix (ECM) organisation …

Loss of muscle mass is a feature of chronic illness and aging. Here, we report that skeletal
muscle-specific thrombospondin-1 transgenic mice (Thbs1 Tg) have profound muscle …