Solid-state NMR: Methods for biological solids

S Ahlawat, KR Mote, NA Lakomek… - Chemical Reviews, 2022 - ACS Publications
In the last two decades, solid-state nuclear magnetic resonance (ssNMR) spectroscopy has
transformed from a spectroscopic technique investigating small molecules and industrial …

SERCA2 phosphorylation at serine 663 is a key regulator of Ca2+ homeostasis in heart diseases

F Gonnot, L Boulogne, C Brun, M Dia, Y Gouriou… - Nature …, 2023 - nature.com
Despite advances in cardioprotection, new therapeutic strategies capable of preventing
ischemia-reperfusion injury of patients are still needed. Here, we discover that sarcoplasmic …

A comprehensive review of the novel therapeutic targets for the treatment of diabetic cardiomyopathy

A Dhar, J Venkadakrishnan, U Roy… - Therapeutic …, 2023 - journals.sagepub.com
Diabetic cardiomyopathy (DCM) is characterized by structural and functional abnormalities
in the myocardium affecting people with diabetes. Treatment of DCM focuses on glucose …

SERCA interacts with chitin synthase and participates in cuticular chitin biogenesis in Drosophila

W Zhu, Y Duan, J Chen, H Merzendorfer, X Zou… - Insect Biochemistry and …, 2022 - Elsevier
The biogenesis of chitin, a major structural polysaccharide found in the cuticle and
peritrophic matrix, is crucial for insect growth and development. Chitin synthase, a …

Analysis of coordinated NMR chemical shifts to map allosteric regulatory networks in proteins

E Skeens, GP Lisi - Methods, 2023 - Elsevier
The exquisite sensitivity of the NMR chemical shift to local environment makes it an ideal
probe to assess atomic level perturbations in proteins of all sizes and structural …

Integrated cellular response of the zebrafish (Danio rerio) heart to temperature change

JB Shaftoe, J Geddes-McAlister… - Journal of Experimental …, 2024 - journals.biologists.com
ABSTRACT A decrease in environmental temperature represents a challenge to the
cardiovascular system of ectotherms. To gain insight into the cellular changes that occur …

Fluxapyroxad induced toxicity of earthworms: Insights from multi-level experiments and molecular simulation studies

L Zhang, Y Liu, Y Xu, M Pei, M Yao, X Chen… - Journal of Hazardous …, 2024 - Elsevier
Fluxapyroxad, an emerging succinate dehydrogenase inhibitor fungicide, is widely used due
to its excellent properties. Given its persistence in soil with a 50% disappearance time of 183 …

[HTML][HTML] Analysis of reproductive damage in earthworms (Amynthas corticis) exposed to cypermethrin

XZ Zhu, ZP Xiong, SP Zhou, SD Xie, HJ Li, QS Li… - Ecotoxicology and …, 2022 - Elsevier
Cypermethrin contamination was a potential threat to soil organisms. In the present work,
reproductive damage in earthworms (Amynthas corticis) exposed to cypermethrin was …

[HTML][HTML] Interaction between A-kinase anchoring protein 5 and protein kinase A mediates CaMKII/HDAC signaling to inhibit cardiomyocyte hypertrophy after hypoxic …

X Zhang, Q Wang, Z Wang, H Zhang, F Zhu, J Ma… - Cellular …, 2023 - Elsevier
We reported that A-kinase anchoring protein 5 (AKAP5) played a role in cardiomyocyte
apoptosis after hypoxia-reoxygenation (H/R). The role of AKAP5 in cardiomyocyte …

[HTML][HTML] Dilated cardiomyopathy variant R14del increases phospholamban pentamer stability, blunting dynamic regulation of calcium

SR Cleary, ACT Teng, AD Kongmeneck, X Fang… - Journal of Biological …, 2025 - Elsevier
The sarco (endo) plasmic reticulum Ca 2+ ATPase (SERCA) is a membrane transporter that
creates and maintains intracellular Ca 2+ stores. In the heart, SERCA is regulated by an …