Cystic Fibrosis (CF) is a genetic disorder that arises due to mutations in the Cystic Fibrosis
Transmembrane Conductance Regulator gene, which encodes for a protein responsible for …

This review focuses on the role and regulation of mucin glycoproteins (mucins) in airway
health and disease. Mucins are highly glycosylated macromolecules (≥ 50% carbohydrate …

For more than a decade, tumor immunologists have focused their efforts on discovering
tumor-associated antigens, as a first step toward the design of an effective cancer vaccine …

Cystic Fibrosis (CF) is a frequent and lethal autosomal recessive disease, caused by
mutations in the gene encoding the Cystic Fibrosis Transmembrane Conductance Regulator …

The specific role of the chloride anion (Cl−) as a signalling effector or second messenger
has been increasingly recognized in recent years. It could represent a key factor in the …

Mucus overproduction and hypersecretion are commonly observed in chronic inflammatory
lung disease. Mucins are gel‐forming glycoproteins that can be stimulated by a variety of …

Background/Aims: Cystic Fibrosis (CF) is caused by mutations in the CFTR gene, encoding
a cAMP-activated chloride (Cl-) channel. We have previously demonstrated that the …

Chronic obstructive pulmonary disease (COPD) and cystic fibrosis (CF) are lethal pulmonary
diseases. Cigarette consumption is the main cause for development of COPD, while CF is …

MUC1, a transmembrane glycoprotein of the mucin family, when aberrantly expressed on
breast cancer cells is correlated with increased lymph node metastases. We have previously …

The impairment of the cystic fibrosis transmembrane conductance regulator (CFTR) activity
induces intracellular chloride (Cl–) accumulation. The anion Cl–, acting as a second …