This review provides a detailed look at the attributes and immunologic mechanisms of
plasmid DNA vaccines and their utility as laboratory tools as well as potential human …

Efforts to make vaccines against infectious diseases as well as immunotherapies for cancer,
autoimmune diseases and allergy have utilized a variety of heterologous expression …

Replication-defective adenoviruses have been utilized as candidate HIV vaccine vectors.
Few studies have described the international epidemiology of pre-existing immunity to …

There is an urgent need to develop new tuberculosis (TB) vaccines to safely and effectively
boost Bacille Calmette-Guérin (BCG)–triggered T cell immunity in humans. AdHu5Ag85A is …

Rationale: AERAS-402 is a novel tuberculosis vaccine designed to boost immunity primed
by bacillus Calmette-Guérin (BCG), the only licensed vaccine. Objectives: We investigated …

Background. We report the first-in-human safety and immunogenicity assessment of a
prototype Ad26 vector-based human immunodeficiency virus (HIV) vaccine in humans …

Summary Background The HVTN 503/Phambili study, which assessed the efficacy of the
Merck Ad5 gag/pol/nef subtype B HIV-1 preventive vaccine in South Africa, was stopped …

The development of a safe, effective and globally affordable HIV vaccine offers the best
hope for the future control of the HIV-1 pandemic. Since 1987, scores of candidate HIV-1 …

Abstract Recombinant adenovirus serotype 5 (Ad5) vectors have been studied extensively in
preclinical gene therapy models and in a range of clinical trials. However, innate immune …

The speed of development and the magnitude of efficacy of recently developed vaccines
directed against SARS-CoV-2 has been truly remarkable. This editorial will not summarize …