UDP-glycosyltransferases (UGTs) catalyze the covalent addition of sugars to a broad range
of lipophilic molecules. This biotransformation plays a critical role in elimination of a broad …

The global pandemic of drug-sensitive cancers and the increasing threat from drug-resistant
cancers make an urgent need to develop more effective anti-cancer candidates. Quinolone …

This review summarized the current breakthroughs in the chemistry of acridines as anti-
cancer agents, including new structural and biologically active acridine attributes. Acridine …

Glucuronidation is an important metabolic pathway for many small endogenous and
exogenous lipophilic compounds, including bilirubin, steroid hormones, bile acids …

The development of drug resistance and severe side-effects has reduced the clinical efficacy
of the existing anti-cancer drugs available in the market. Thus, there is always a constant …

Hybridization, a strategy based on the covalent fusion of two or more existing
pharmacophores to create a single molecule with multiple mechanisms of action, represents …

The final therapeutic effect of a drug candidate, which is directed to a specific molecular
target strongly depends on its absorption, distribution, metabolism and excretion (ADME) …

UGTs play crucial roles in the metabolism and detoxification of both endogenous and
xenobiotic compounds. The key roles of UGTs in human health have garnered great interest …

The clinical effectiveness of the available anticancer drugs has been reduced due to the
development of drug resistance and serious adverse effects, which have restricted …

Dynamic monitoring of the uridine diphosphate glucuronosyltransferase 1A1 (UGT1A1) is of
great significance for the diagnosis and treatment of UGT1A1-related metabolic diseases …