Tuberculous meningitis: pathogenesis, immune responses, diagnostic challenges, and the potential of biomarker-based approaches

CM Manyelo, RS Solomons, G Walzl… - Journal of clinical …, 2021 - Am Soc Microbiol
Tuberculous meningitis (TBM) is the most devastating form of tuberculosis (TB), causing
high mortality or disability. Clinical management of the disease is challenging due to …

The Role of microRNAs and Long Non-Coding RNAs in the Regulation of the Immune Response to Mycobacterium tuberculosis Infection

M Kundu, J Basu - Frontiers in immunology, 2021 - frontiersin.org
Non-coding RNAs have emerged as critical regulators of the immune response to infection.
MicroRNAs (miRNAs) are small non-coding RNAs which regulate host defense mechanisms …

MicroRNAs as immune regulators and biomarkers in tuberculosis

L Wang, Y Xiong, B Fu, D Guo, MY Zaky, X Lin… - Frontiers in …, 2022 - frontiersin.org
Tuberculosis (TB), which is caused by Mycobacterium tuberculosis (Mtb), is one of the most
lethal infectious disease worldwide, and it greatly affects human health. Some diagnostic …

Monocyte and macrophage miRNA: potent biomarker and target for host-directed therapy for tuberculosis

P Sampath, KM Periyasamy, UD Ranganathan… - Frontiers in …, 2021 - frontiersin.org
The end TB strategy reinforces the essentiality of readily accessible biomarkers for early
tuberculosis diagnosis. Exploration of microRNA (miRNA) and pathway analysis opens an …

miRNAs in immune responses to Mycobacterium tuberculosis infection

T Yang, B Ge - Cancer letters, 2018 - Elsevier
Tuberculosis (TB) is one of the most fatal infectious diseases, affecting one third of the
world's population. The causative agent, Mycobacterium tuberculosis (Mtb), has a well …

ITIH4 acts as a protease inhibitor by a novel inhibitory mechanism

R Pihl, RK Jensen, EC Poulsen, L Jensen… - Science …, 2021 - science.org
Inter-α-inhibitor heavy chain 4 (ITIH4) is a poorly characterized plasma protein that is
proteolytically processed in multiple pathological conditions. However, no biological function …

Proteomics in biomarker discovery for tuberculosis: current status and future perspectives

J Guo, X Zhang, X Chen, Y Cai - Frontiers in Microbiology, 2022 - frontiersin.org
Tuberculosis (TB) continues to threaten many peoples' health worldwide, regardless of their
country of residence or age. The current diagnosis of TB still uses mainly traditional, time …

Proteomics approaches: A review regarding an importance of proteome analyses in understanding the pathogens and diseases

M Zubair, J Wang, Y Yu, M Faisal, M Qi… - Frontiers in Veterinary …, 2022 - frontiersin.org
Proteomics is playing an increasingly important role in identifying pathogens, emerging and
re-emerging infectious agents, understanding pathogenesis, and diagnosis of diseases …

From simple to complex: Protein‐based biomarker discovery in tuberculosis

Z Mousavian, G Källenius… - European Journal of …, 2023 - Wiley Online Library
Tuberculosis (TB) is a deadly infectious disease that affects millions of people globally. TB
proteomics signature discovery has been a rapidly growing area of research that aims to …

MicroRNAs as diagnostic biomarkers for tuberculosis: a systematic review and meta-analysis

EA Daniel, B Sathiyamani, K Thiruvengadam… - Frontiers in …, 2022 - frontiersin.org
Background The early diagnosis of tuberculosis using novel non-sputum-based biomarkers
is of high priority in the End TB strategy. MicroRNAs (miRNAs) are significant regulators of …