Tumorigenesis is a highly complex process, involving many interrelated and cross-acting
signalling pathways. One such pathway that has garnered much attention in the field of …

G protein‐coupled receptors (GPCRs) and heterotrimeric G proteins play central roles in a
diverse array of cellular processes. As such, dysregulation of GPCRs and their coupled …

GPCRs are master regulators of cell signaling by transducing extracellular stimuli into the
cell via selective coupling to intracellular G-proteins. Here we present a computational …

G protein–coupled receptors (GPCRs) are the largest gene family of cell membrane–
associated molecules mediating signal transmission, and their involvement in key …

Many of the fundamental concepts of signal transduction and kinase activity are attributed to
the discovery and crystallization of cAMP-dependent protein kinase, or protein kinase A …

The need to make sense of the thousands of genetic variants uncovered every day in terms
of pathology or biological mechanism is acute. Many insights into how genetic changes …

G protein-coupled receptors (GPCRs) are the largest family of human proteins. They have a
common structure and, signaling through a much smaller set of G proteins, arrestins, and …

In this study we show that protein language models can encode structural and functional
information of GPCR sequences that can be used to predict their signaling and functional …

We employed a multifaceted computational strategy to identify the genetic factors
contributing to increased risk of severe COVID-19 infection from a Whole Exome …

Prostate cancer (PRAD) is a common and fatal malignancy. It is difficult to manage clinically
due to drug resistance and poor prognosis, thus creating an urgent need for novel …