Dual-targeted NAMPT inhibitors as a progressive strategy for cancer therapy

F Ozgencil, HB Gunindi, G Eren - Bioorganic Chemistry, 2024 - Elsevier
In mammals, nicotinamide phosphoribosyltransferase (NAMPT) is a crucial enzyme in the
nicotinamide adenine dinucleotide (NAD+) synthesis pathway catalyzing the condensation …

Effect of stress on hormone levels in the blood serum of rats with alimentary obesity

VV Shotaev, KR Doshkhokloeva… - …, 2024 - pharmacophorejournal.com
Chronic stress, along with burdened heredity, a sedentary lifestyle, and an unbalanced diet,
is one of the causes of obesity [1, 2]. It is well known that under stress, excessive release of …

[HTML][HTML] Mesenchymal stem cells arouse myocardial NAD+ metabolism to alleviate microgravity-induced cardiac dysfunction

C Zhang, Y Yuan, S Zhang, N Yan, Y Zhao, L Lu… - Biochemical and …, 2024 - Elsevier
After prolonged space operations, astronauts showed maladaptive atrophy within mostly left-
ventricular myocardium, resulting in cardiac dysfunction. However, the mechanism of …