Pancreatic cancer remains a lethal malignancy with poor prognosis owing to therapeutic
resistance, frequent recurrence and the absence of treatment strategies that specifically …

Integrins are transmembrane receptors that coordinate extracellular matrix (ECM)–cell and
cell–cell interactions, signal transmission, gene expression, and cell function. The aberration …

Background: Cancer has profound effects on gene expression, including a cell's
glycosylation machinery. Thus, tumors produce glycoproteins that carry oligosaccharides …

Cells are covered with a dense layer of carbohydrates, some of which are solely present on
neoplastic cells. The so-called tumor-associated carbohydrate antigens (TACAs) are …

Glycosylation is the most commonly occurring post-translational modifications, and is
believed to modify over 50% of all proteins. The process of glycan modification is directed by …

The O‐glycan branching enzyme, core2 β‐1, 6‐N‐acetylglucosaminyltransferase (C2GnT),
forms O‐glycans containing an N‐acetylglucosamine branch connected to N …

Background Colon cancer (CC) is the second most common gastrointestinal malignancy.
About one in five patients have already developed distant metastases at the time of initial …

This review is the sixth update of the original article published in 1999 on the application of
MALDI mass spectrometry to the analysis of carbohydrates and glycoconjugates and brings …

The α2β1 integrin, also known as VLA-2, GPIa-IIa, CD49b, was first identified as an
extracellular matrix receptor for collagens and/or laminins [55, 56]. It is now recognized that …

While a protein primary structure is determined by genetic code, its specific functional form is
mostly achieved in a dynamic interplay that includes actions of many enzymes involved in …