Reelin is an extracellular matrix protein that is mainly produced in Cajal-Retzius cells and
controls neuronal migration, which is important for the proper formation of cortical layers in …

Background Long-read whole genome sequencing (lrWGS) has the potential to address the
technical limitations of exome sequencing in ways not possible by short-read WGS …

Hepatocellular carcinoma (HCC) is one of the most fatal and fastest growing malignancies.
Recently, nonalcoholic steatohepatitis (NASH), characterized by liver steatosis …

Abstract Mammalian sterile 20-like (Ste20-like) protein kinase 3 (MST3) or serine/threonine-
protein kinase 24 (STK24) is a serine/threonine protein kinase that belongs to the …

Background: Cavernous cerebral malformations can arise because of mutations in the
CCM1, CCM2, or CCM3 genes, and lack of Cdc42 has also been reported to induce these …

Dendritic spine formation/maintenance is highly dependent on actin cytoskeletal dynamics,
which is regulated by small GTPases Rac1 and Cdc42 through their downstream p21 …

Whole exome sequencing/whole genome sequencing has accelerated the identification of
novel genes associated with intellectual disabilities (ID), and RAB11A which encodes an …

Glioblastoma is the deadliest brain cancer. One of the main reasons for poor outcome
resides in therapy resistance, which adds additional challenges in finding an effective …

Background ARF (ADP-ribosylation factor) GTPases are major regulators of intracellular
trafficking, and classified into 3 groups (Type I–III), among which the type I group members …

目的: 探讨丝氨酸/苏氨酸蛋白激酶25 (serine/threonine protein kinase 25, STK25)
对星形胶质细胞活化及实验性自身免疫性脑脊髓炎(experimental autoimmune …