Alopecia areata: an update on etiopathogenesis, diagnosis, and management

C Zhou, X Li, C Wang, J Zhang - Clinical Reviews in Allergy & …, 2021 - Springer
Alopecia areata (AA) is a common chronic tissue-specific autoimmune disease, resulting in
hair loss, that affects up to 2% of the general population. The exact pathobiology of AA has …

Hair follicle immune privilege and its collapse in alopecia areata

M Bertolini, K McElwee, A Gilhar… - Experimental …, 2020 - Wiley Online Library
Anagen stage hair follicles (HFs) exhibit “immune privilege (IP)” from the level of the bulge
downwards to the bulb. Both passive and active IP mechanisms protect HFs from …

Alopecia areata: disease characteristics, clinical evaluation, and new perspectives on pathogenesis

LC Strazzulla, EHC Wang, L Avila, KL Sicco… - Journal of the American …, 2018 - Elsevier
Alopecia areata (AA) is a common, inflammatory, nonscarring type of hair loss. Significant
variations in the clinical presentation of AA have been observed, ranging from small, well …

An overview of JAK/STAT pathways and JAK inhibition in alopecia areata

M Lensing, A Jabbari - Frontiers in immunology, 2022 - frontiersin.org
Alopecia Areata (AA) is a common autoimmune disease characterized by non-scarring hair
loss ranging from patches on the scalp to complete hair loss involving the entire body …

Alopecia areata: a review of disease pathogenesis

F Rajabi, LA Drake, MM Senna… - British Journal of …, 2018 - academic.oup.com
Background Alopecia areata is a disorder that results in nonscarring hair loss. The
psychological impact can be significant, leading to feelings of depression and social …

Alopecia areata is driven by cytotoxic T lymphocytes and is reversed by JAK inhibition

L Xing, Z Dai, A Jabbari, JE Cerise, CA Higgins… - Nature medicine, 2014 - nature.com
Alopecia areata (AA) is a common autoimmune disease resulting from damage of the hair
follicle by T cells. The immune pathways required for autoreactive T cell activation in AA are …

Phase 2a randomized clinical trial of dupilumab (anti‐IL‐4Rα) for alopecia areata patients

E Guttman‐Yassky, Y Renert‐Yuval, J Bares… - Allergy, 2022 - Wiley Online Library
Background Treatments for alopecia areata (AA) patients with extensive scalp hair loss are
limited, and recent evidence supports a role for type 2 T‐cell (Th2)‐immune response in AA …

Baricitinib for the treatment of alopecia areata

E Freitas, E Guttman-Yassky, T Torres - Drugs, 2023 - Springer
Alopecia areata (AA) is a relapsing, chronic, immune-mediated disease characterized by
nonscarring, inflammatory hair loss that can affect any hair-bearing site. AA clinical …

Alopecia areata–Current understanding and management

DA Lintzeri, A Constantinou, K Hillmann… - JDDG: Journal der …, 2022 - Wiley Online Library
Alopecia areata (AA) is a chronic, immune‐mediated disease characterized by acute or
chronic non‐scarring hair loss, with a heterogeneity in clinical manifestations ranging from …

Lymphocytes, neuropeptides, and genes involved in alopecia areata

A Gilhar, R Paus, RS Kalish - The Journal of clinical …, 2007 - Am Soc Clin Investig
Many lessons in autoimmunity—particularly relating to the role of immune privilege and the
interplay between genetics and neuroimmunology—can be learned from the study of …