Stem cell transplantation holds great promise as a potential treatment for currently incurable
retinal degenerative diseases that cause poor vision and blindness. Recently, safety data …

Mammalian retinal degenerations initiated by gene defects in rods, cones or the retinal
pigmented epithelium (RPE) often trigger loss of the sensory retina, effectively leaving the …

Photoreceptor loss causes irreversible blindness in many retinal diseases. Repair of such
damage by cell transplantation is one of the most feasible types of central nervous system …

Recent reports have supported the existence of neural stem cells in the adult mammalian
CNS. Important features of such cells are self-renewal and multipotency, ie, they can give …

Many photoreceptor degenerations initially affect rods, secondarily leading to cone death. It
has long been assumed that the surviving neural retina is largely resistant to this sensory …

It has long been believed that the retina of mature mammals is incapable of regeneration. In
this study, using the N-methyl-d-aspartate neurotoxicity model of adult rat retina, we …

Recent work in neuroscience has shown that the adult central nervous system contains
neural progenitors, precursors, and stem cells that are capable of generating new neurons …

This study identifies and characterizes retinal stem cells (RSCs) in early postnatal to seventh-
decade human eyes. Different subregions of human eyes were dissociated and cultured by …

Ex vivo cultured limbal epithelial stem cells have been used successfully to treat corneal
limbal stem cell deficiency. We identified 17 reports of the application of this novel cell …

purpose. To use progenitor cells isolated from the neural retina for transplantation studies in
mice with retinal degeneration. methods. Retinal progenitor cells from postnatal day 1 green …