HFIP in organic synthesis

HF Motiwala, AM Armaly, JG Cacioppo… - Chemical …, 2022 - ACS Publications
1, 1, 1, 3, 3, 3-Hexafluoroisopropanol (HFIP) is a polar, strongly hydrogen bond-donating
solvent that has found numerous uses in organic synthesis due to its ability to stabilize ionic …

Recent advances in synthesis of quinazoline‐2,4(1H,3H)‐diones: Versatile building blocks in N‐heterocyclic compounds

D Gheidari, M Mehrdad, S Maleki - Applied Organometallic …, 2022 - Wiley Online Library
Abstract Quinazoline‐2, 4 (1H, 3H)‐dione is a significant class of N‐fused heterocyclic with a
wide range of biological functions, including anti‐HIV, anticancer, antifungal, antibacterial …

Efficient Copper (II)‐Catalyzed Transamidation of Non‐Activated Primary Carboxamides and Ureas with Amines

M Zhang, S Imm, S Bähn, L Neubert… - Angewandte Chemie …, 2012 - infona.pl
Efficient Copper(II)‐Catalyzed Transamidation of Non‐Activated Primary Carboxamides and
Ureas with Amines × Close The Infona portal uses cookies, ie strings of text saved by a …

FeCl3-Mediated Synthesis of 2-(Trifluoromethyl)quinazolin-4(3H)-ones from Isatins and Trifluoroacetimidoyl Chlorides

LC Wang, S Du, Z Chen, XF Wu - Organic Letters, 2020 - ACS Publications
An FeCl3-mediated cascade coupling/decarbonylative annulation reaction for the efficient
construction of 2-(trifluoromethyl) quinazolin-4 (3 H)-ones has been developed. This …

Iron-catalyzed CH and CC bond cleavage: a direct approach to amides from simple hydrocarbons.

C Qin, W Zhou, F Chen, Y Ou, N Jiao - … Chemie (International ed. in …, 2011 - europepmc.org
Something functional: The title reaction proceeds in the presence of azide and water to
deliver amides in high yields, and it can be used in a ring-expansion strategy to generate …

Remodeling and enhancing Schmidt reaction pathways in hexafluoroisopropanol

HF Motiwala, M Charaschanya, VW Day… - The Journal of Organic …, 2016 - ACS Publications
The effect of carrying out two variations of the Schmidt reaction with ketone electrophiles in
hexafluoroisopropanol (HFIP) solvent has been studied. When TMSN3 is reacted with …

Highly enantio-and diastereoselective synthesis of 1, 2, 3-trisubstituted cyclopropanes from α, β-unsaturated amides and stabilized sulfur ylides catalyzed by a chiral …

S K. Pagire, N Kumagai, M Shibasaki - ACS Catalysis, 2021 - ACS Publications
The stereoselective preparation of 1, 2, 3-substituted cyclopropanes from α, β-unsaturated
carbonyl compounds in the carboxylic acid oxidation state through Michael addition-initiated …

Direct amide bond formation from carboxylic acids and amines using activated alumina balls as a new, convenient, clean, reusable and low cost heterogeneous …

S Ghosh, A Bhaumik, J Mondal, A Mallik… - Green chemistry, 2012 - pubs.rsc.org
For the first time, we have used activated alumina balls (3–5 mm diameter) for amide
synthesis from carboxylic acids (unactivated) and amines (unactivated) under neat reaction …

Recent uses of iron catalysts in organic reactions

Liu - Current Organic Chemistry, 2010 - benthamdirect.com
Iron catalysts are extensively used in organic reactions in recent years since iron is one of
the most abundant metals on earth, consequently one of the most inexpensive, and …

The Schmidt reaction

A Wrobleski, TC Coombs, CW Huh, SW Li… - Organic …, 2004 - Wiley Online Library
The classical form of the Schmidt reaction involves the reaction of a carbon‐centered
electrophile with hydrazoic acid with loss of nitrogen, usually with a rearrangement that …